TGF-β1 signaling regulates mouse hepatic stellate cell differentiation via the Jagged1/Notch pathway

Our findings emphasize that the TGF-β1 signaling pathway regulates expression of Jagged1 in mHSCs which is associated with transformation of mHSCs into MFs, thus demonstrating a novel mechanism via which TGF-β1 signaling controls the differentiation fate of mHSCs through regulation of the Jagged1/Notch pathway.