کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8536894 1560922 2018 30 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role of the leukemia inhibitory factor receptor in neuroprotective signaling
ترجمه فارسی عنوان
نقش گیرنده عامل مهار کننده لوسمی در سیگنالینگ عصبی
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
چکیده انگلیسی
Several neurotropic cytokines relay their signaling through the leukemia inhibitory factor receptor. This 190 kDa subunit couples with the 130 kDa gp130 subunit to transduce intracellular signaling in neurons and oligodendrocytes that leads to expression of genes associated with neurosurvival. Moreover, activation of this receptor alters the phenotype of immune cells to an anti-inflammatory one. Although cytokines that activate the leukemia inhibitory factor receptor have been studied in the context of neurodegenerative disease, therapeutic targeting of the specific receptor subunit has been understudied in by comparison. This review examines the role of this receptor in the CNS and immune system, and its application in the treatment in stroke and other brain pathologies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 183, March 2018, Pages 50-57
نویسندگان
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