کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8536989 | 1560925 | 2017 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
MicroRNA and chronic pain: From mechanisms to therapeutic potential
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کلمات کلیدی
DRGCX43CFACRPSCaMKIIBPSCCIcomplete Freund's adjuvant - adjuvant دوست کاملBDNF - BDNF یا فاکتور نورونزایی مشتقشده از مغز Ca2 +/calmodulin-dependent protein kinase II - Ca2 + / calmodulin وابسته پروتئین کیناز IIchronic constriction injury - آسیب زدگی مزمنBladder pain syndrome - سندرم درد مثانهComplex regional pain syndrome - سندرم درد پیچیده منطقه ایBrain-derived neurotrophic factor - فاکتور نوروتروفی مشتق شده از مغزCSF - مایع مغزی نخاعیCerebrospinal fluid - مایع مغزی نخاعیconnexin 43 - کنکنسین 43GABAA - گاباdorsal root ganglia - گانگلیس ریشه پشتی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Chronic pain is a major public health issue with an incidence of 20-25% worldwide that can take different forms like neuropathic, cancer-related or inflammatory pain. Chronic pain often limits patients in their daily activities leading to despair. Thus, the goal of treatments is to relieve pain sufficiently to enable patients to go back to a normal life. Unfortunately, few patients with chronic pain obtain complete relief from the analgesics that are currently available. It is thus of prime importance to get a better understanding of chronic pain mechanisms to design new therapeutic strategies and pain-killers. In this sense, the study of microRNA (miRNAs) in chronic pain conditions could lead to a breakthrough in pain management. miRNAs have emerged as master regulators of gene expression in the nervous system where they contribute to neuronal network plasticity. The involvement of miRNAs in the maladaptive plasticity mechanisms of chronic pain is now well documented. Here, we review studies conducted in different animal models and in patients that screened chronic pain-related miRNAs and their targets. Clinical studies suggest that miRNAs expression could reflect the high variability among pain patients that could help to categorize patients and finally lead to personalized therapies. We also point out the different strategies investigated to design miRNA-based analgesics. Finally, we highlight the current miRNA-based clinical trials to hypothesize their potential as therapeutic tool for chronic pain.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 180, December 2017, Pages 1-15
Journal: Pharmacology & Therapeutics - Volume 180, December 2017, Pages 1-15
نویسندگان
MarÃa José López-González, Marc Landry, Alexandre Favereaux,