کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8537202 | 1561007 | 2018 | 21 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The acute and residual effects of escalating, analgesic-range doses of ketamine on driving performance: A simulator study
ترجمه فارسی عنوان
اثرات حاد و باقی مانده از افزایش و تقسیم دوزهای کتامین در عملکرد رانندگی: یک مطالعه شبیه ساز
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
Ketamine hydrochloride elicits potent psychotomimetic and neurobehavioural effects which make it incompatible with driving; however, the direct effect on driving performance is yet to be assessed. Using an open label, within-subjects protocol, 15 males and 5 females (mean ageâ¯=â¯30.8â¯years) were administered three fixed, stepwise increasing sub-anaesthetic doses of intravenous (IV) ketamine solution [(i) 8â¯mg/h IV infusion plus 30â¯mg bolus, (ii) 12â¯mg/h IV infusion and (iii) 20â¯mg/h infusion]. Whole blood ketamine and norketamine concentrations were determined at each treatment step and at 2â¯h post-infusion. Driving performance was assessed at baseline, at each treatment step and at 2â¯h post-treatment using a validated computerised driving simulator. Standard Deviation of Lateral Position (SDLP) and Steering Variability (SV) were assessed. Linear Fixed Effect Modelling indicated a main effect for time (dose) for SDLP (F[4,72]â¯=â¯33.22, pâ¯<â¯0.0001) and SV (F[4,72]â¯=â¯4.65, pâ¯<â¯0.002). Post-hoc analyses revealed significant differences from baseline at each treatment step for SDLP (all pâ¯<â¯0.001), and for 12â¯mg/h treatment step for SV (pâ¯=â¯0.049). Post-treatment driving performance returned to baseline levels. Weak positive linear associations were observed between SDLP and whole blood ketamine concentrations (R2â¯=â¯0.11, βâ¯=â¯29.96, pâ¯=â¯0.001) and norketamine (R2â¯=â¯0.09, βâ¯=â¯28.87, pâ¯=â¯0.003). These findings suggest that even under highly controlled conditions, ketamine intoxication significantly alters simulated driving performance. At the highest dose, ketamine produced changes to SDLP considered incompatible with safe driving, highlighting how ketamine consumption may translate to an increased risk of road trauma.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 86, 30 August 2018, Pages 83-88
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 86, 30 August 2018, Pages 83-88
نویسندگان
Amie C. Hayley, Maja Green, Luke A. Downey, Con K.K. Stough, Michael Keane, Brook Shiferaw, Panagiota Kostakis, Yahya Shehabi,