کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8537242 | 1561008 | 2018 | 37 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hyperglycemia elicits anxiety-like behaviors in zebrafish: Protective role of dietary diphenyl diselenide
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
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چکیده انگلیسی
Diabetes mellitus (DM) is a chronic metabolic disease that may comorbid with various psychiatric disorders, such as anxiety and depression. The search for effective therapeutics to alleviate hyperglycemia and complications resulting from DM is continuous. Here we investigate the effects of diphenyl diselenide (DD), an organoselenium compound with several pharmacological properties, in a zebrafish model of hyperglycemia. Fish were fed for 74â¯days with a diet containing 3â¯mg/Kg DD, a concentration chosen after experiments based in a dose-response curve (DD 1, 2 and 3â¯mg/Kg) that did not cause overt toxicity (mortality, weight loss and neurobehavioral deficits). In the last 14â¯days of the experimental period, fish were concomitantly exposed to a glucose solution (111â¯mM). Afterwards, blood glucose levels, brain selenium (Se) content, and behavioral analysis aiming to assess anxiety-like behaviors and locomotor/exploratory activities were performed. In the novel tank diving test, glucose decreased vertical exploration and fish spent less time in the lit area when tested in the light-dark test, suggesting increased anxiety-like behavior. Moreover, DD decreased blood glucose levels in hyperglycemic fish as well as prevented the development of anxiety-related symptoms. DD diet alone did not change glycemia and behavioral parameters, but increased Se levels in the brain without affecting the cellular viability. Collectively, our findings highlight the growing utility of this zebrafish hyperglycemia model as a valuable strategy for further research in DM field and neuroprotective approaches.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 85, 13 July 2018, Pages 128-135
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 85, 13 July 2018, Pages 128-135
نویسندگان
Matheus M. dos Santos, Gabriel T. de Macedo, Alessandro S. Prestes, Vânia L. Loro, Graciela M. Heidrich, Rochele S. Picoloto, Denis B. Rosemberg, Nilda V. Barbosa,