Glutamatergic synapses in neurodevelopmental disorders

ADHD (Attention-deficit hyperactivity disorder): ADHD is probably the most complex of NDDs with very little knowledge on specific mechanisms involving glutamate. Nowadays, several mutations on genes encoding for NMDARs subunits, GRIN2A and GRIN2B, and for mGluRs, GRM1, GRM5, GRM7 and GRM8, have been linked to this pathology.340