کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8538859 | 1561121 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Low-level arsenic causes proteotoxic stress and not oxidative stress
ترجمه فارسی عنوان
آرسنیک با سطح پایین باعث استئوآرتریت و استرس اکسیداتیو می شود
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کلمات کلیدی
IRE-1Autophagy inhibitorsequestosome 1XBP1SDcfATF6LC32′,7′-dichlorodihydrofluorescein diacetate - 2 '، 7'-dichlorodihydrofluorescein diacetate2′,7′-dichlorofluorescein - 2 '، 7'-dichlorofluorescein3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide - 3- (4،5-dimethyl-2-thiazolyl) -2،5-difenyl-2H-tetrazolium bromideH2DCFDA - H2DCFD بهMTT - MTTROS - ROSSQSTM1/p62 - SQSTM1 / p62Arsenic - آرسنیکinositol-requiring enzyme 1 - آنزیم مورد نیاز inositol 1ER stress - استرس استOxidative stress - تنش اکسیداتیوactivating transcription factor 6 - فعال کردن عامل رونویسی 6Proteostasis - پروتئوستازPERK - پرکReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Prolonged exposure to arsenic has been shown to increase the risk of developing a number of diseases, including cancer and type II diabetes. Arsenic is present throughout the environment in its inorganic forms, and the level of exposure varies greatly by geographical location. The current recommended maximum level of arsenic exposure by the EPA is 10 μg/L, but levels > 50-1000 μg/L have been detected in some parts of Asia, the Middle East, and the Southwestern United States. One of the most important steps in developing treatment options for arsenic-linked pathologies is to understand the cellular pathways affected by low levels of arsenic. Here, we show that acute exposure to non-lethal, low-level arsenite, an environmentally relevant arsenical, inhibits the autophagy pathway. Furthermore, arsenite-induced autophagy inhibition initiates a transient, but moderate ER stress response. Significantly, low-level arsenite exposure does not exhibit an increase in oxidative stress. These findings indicate that compromised autophagy, and not enhanced oxidative stress occurs early during arsenite exposure, and that restoring the autophagy pathway and proper proteostasis could be a viable option for treating arsenic-linked diseases. As such, our study challenges the existing paradigm that oxidative stress is the main underlying cause of pathologies associated with environmental arsenic exposure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology and Applied Pharmacology - Volume 341, 15 February 2018, Pages 106-113
Journal: Toxicology and Applied Pharmacology - Volume 341, 15 February 2018, Pages 106-113
نویسندگان
Matthew Dodson, Montserrat Rojo de la Vega, Bryan Harder, Raul Castro-Portuguez, Silvia D. Rodrigues, Pak Kin Wong, Eli Chapman, Donna D. Zhang,