کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8540553 1561220 2018 32 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inorganic nitrite and nitrate in cardiovascular therapy: A better alternative to organic nitrates as nitric oxide donors?
ترجمه فارسی عنوان
نیتریت و نیترات معدنی در درمان قلب و عروق: جایگزینی بهتر برای نیترات های آلی به عنوان اهداکنندگان اکسید نیتریک؟
کلمات کلیدی
نیتریت و نیترات معدنی، سبزیجات، عملکرد عروقی، فشار خون، استرس اکسیداتیو، التهاب
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی
In 1867 the organic nitrite, amyl nitrite, was introduced as a therapeutic agent in the treatment of angina pectoris and was later substituted by the organic nitrate nitroglycerin (NTG). Despite having a highly potent vasodilator capacity in veins > coronary arteries > arterioles, the vasodilator effects NTG are rapidly attenuated by the development of nitrate tolerance. We and others established that NTG treatment stimulates the production of reactive oxygen species such as superoxide and peroxynitrite with subsequent marked attenuation of the NTG vasodilator potency. The nitrite anion (NO2−) has more recently been characterized to possess novel pharmacotherapeutic actions such as modulation of vasodilation under hypoxic conditions, thereby providing protection in ischemia-reperfusion injury. Administration of NO2−/NO3− has also been shown to improve myocardial function in heart failure and to lower blood pressure. Despite these positive aspects there is still a great need to study inorganic nitrate and nitrite therapy in various cardiovascular diseases in prospective outcome directed studies. In case being successful, this kind of therapy would indeed represent a cheap, therefore affordable, effective cardiovascular therapy without major side effects as observed in response to therapy with organic nitrates.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vascular Pharmacology - Volume 102, March 2018, Pages 1-10
نویسندگان
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