کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8546072 | 1561687 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hydrogen sulfide protects neonatal rat medulla oblongata against prenatal cigarette smoke exposure via anti-oxidative and anti-inflammatory effects
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کلمات کلیدی
Anti-oxidative effectMDAIL-6CSEMedulla oblongataIL-1βGSHRT-PCRAnti-inflammatory effect - اثر ضد التهابیinterleukin-6 - اینترلوکین ۶Interleukin-1β - اینترلوکین-1βtumor necrosis factor-α - تومور نکروز عامل αSOD - سدHydrogen sulfide - سولفید هیدروژنSuperoxide dismutase - سوکسوکس دیسموتازTNF-α - فاکتور نکروز توموری آلفاcigarette smoke exposure - قرار گرفتن در معرض سیگارmalondialdehyde - مالون دی آلدهیدreverse transcription-polymerase chain reaction - واکنش زنجیره ای رونویسی-پلیمراز معکوسoptical density - چگالی نوریGlutathione - گلوتاتیون
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Hydrogen sulfide protects neonatal rat medulla oblongata against prenatal cigarette smoke exposure via anti-oxidative and anti-inflammatory effects Hydrogen sulfide protects neonatal rat medulla oblongata against prenatal cigarette smoke exposure via anti-oxidative and anti-inflammatory effects](/preview/png/8546072.png)
چکیده انگلیسی
We previously demonstrated that hydrogen sulfide (H2S) protected neonatal rat medulla oblongata from prenatal cigarette smoke exposure (CSE) via anti-apoptotic effect. The present work further investigated the involvement of anti-oxidative and anti-inflammatory effects of H2S in the protection. Pregnant Sprague-Dawley rats were randomly divided into NaCl, CSE, CSEâ¯+â¯NaHS (a donor of H2S) and NaHS groups. All the tests were performed with corresponding neonatal rats. Nissl staining revealed that NaHS treatment ameliorated neuronal chromatolysis in the hypoglossal nucleus and nucleus ambiguus resulted from prenatal CSE. Moreover, NaHS eliminated decrease of glutathione level, increase of malondialdehyde content and inhibition of superoxide dismutase activity within neonatal rat medulla oblongata caused by prenatal CSE. NaHS also relieved the up-regulation of tumor necrosis factor-α, interleukin-1β and interleukin-6 in the medulla oblongata of the neonatal CSE rats. These results suggest that H2S can alleviate prenatal CSE-induced injuries of neonatal rat medulla oblongata through anti-oxidative and anti-inflammatory effects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 57, January 2018, Pages 151-158
Journal: Environmental Toxicology and Pharmacology - Volume 57, January 2018, Pages 151-158
نویسندگان
Xiang Yan, Fang Lei, Yajie Hu, Lihong Nie, Qingyi Jia, Hua Zhou, Fusheng Zhao, Yu Zheng,