کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8550533 | 1562038 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Consequences of lead exposure, and it's emerging role as an epigenetic modifier in the aging brain
ترجمه فارسی عنوان
پیامدهای قرار گرفتن در معرض سرب، و نقش در حال ظهور آن به عنوان یک اصلاح کننده اپی ژنتیک در مغز پیری است
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Lead exposure has primarily been a concern during development in young children and little attention has been paid to exposure outcomes as these children age, or even to exposures in adulthood. Childhood exposures have long term consequences, and adults who have been exposed to lead as children show a host of cognitive deficits. Lead has also been shown to induce latent changes in the aging brain, and has been implicated in the pathogenesis of neurodegenerative diseases, particularly Alzheimer's Disease, and Parkinson's. Recent research has shown that lead has the ability to alter DNA methylation, histone modifications, and miRNA expression in experimental models, and in humans. These findings implicate epigenetics in lead induced toxicity, and long term changes in individuals. Epigenetic modification could potentially provide us a mechanism by which the environment, and toxic exposures contribute to the increased susceptibility of adult neurodegenerative disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroToxicology - Volume 56, September 2016, Pages 254-261
Journal: NeuroToxicology - Volume 56, September 2016, Pages 254-261
نویسندگان
Aseel Eid, Nasser Zawia,