کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8551172 | 1562107 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Safety assessment of vitacoxib: 180-day chronic oral toxicity studies
ترجمه فارسی عنوان
ارزیابی ایمنی ویتاکوکسیب: مطالعات سمیت مزمن خوراکی 180 روزه
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Vitacoxib, a selective COX-2 inhibitor, is approved for the relief of pain and inflammation associated with orthopedic surgery and osteoarthritis in dogs. In the current study, a chronic toxicity research was performed to evaluate the safety of vitacoxib in male and female rats for long-term. Vitacoxib was dosed orally to groups of rats for 180 days at 1.2, 6, 30â¯mg/kgâ¯bw/day by gavage. The chronic study oral administration of vitacoxib did not show observational or toxicological effects on the body or organ weights, food consumption, hematology and biochemistry at dose 6â¯mg/kg bw. However, vitacoxib (30â¯mg/kg) showed minor alterations to histopathology of liver, kidney and stomach related to treatment. These results provide further indication that vitacoxib is safe and well-tolerated in rats after 180 days of daily oral administration at 6â¯mg/kg bw and the NOAEL for both sexes was 6â¯mg/kg bw for 180 consecutive days.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 95, June 2018, Pages 244-249
Journal: Regulatory Toxicology and Pharmacology - Volume 95, June 2018, Pages 244-249
نویسندگان
Jianzhong Wang, Tingting Zhao, Shusheng Tang, Suxia Zhang, Pengyyue Lv, Jing Li, Xingyuan Cao,