کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8551196 | 1562107 | 2018 | 22 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Neuroprotective effect of the carnosine - α-lipoic acid nanomicellar complex in a model of early-stage Parkinson's disease
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کلمات کلیدی
5-HTMDA3-MTDOPACMPTPLPO4-hydroxynonenal4-HNE1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine - 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine5-Hydroxyindoleacetic acid - 5-هیدروکسی سدیم اسیدROS - ROSα-Lipoic acid - اسید α-لیپوئیکHomovanilic acid - اسید هومیانیلیکHIAA - بالاParkinson's disease - بیماری پارکینسونOxidative stress - تنش اکسیداتیوDopamine - دوپامینmalonic dialdehyde - دی دی هایید ملونNeuroprotection - محافظت نورونی یا محافظت از عصبRat - موش صحراییnoradrenalin - نورآدرنالینLipid peroxidation - پراکسیداسیون لیپیدHVA - چهcatecholamines - کاتکول امینCarnosine - کارنوزینhigh-performance liquid chromatography - کروماتوگرافی مایعی کاراHPLC - کروماتوگرافی مایعی کاراReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Neuroprotective effect of the carnosine - α-lipoic acid nanomicellar complex in a model of early-stage Parkinson's disease Neuroprotective effect of the carnosine - α-lipoic acid nanomicellar complex in a model of early-stage Parkinson's disease](/preview/png/8551196.png)
چکیده انگلیسی
In a model of early-stage Parkinson's disease induced by a single intranasal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to Wistar rats, a neuroprotective effect of a new derivative of carnosine and α-lipoic acid (C/LA nanomicellar complex) was demonstrated. Acute intraperitoneal administration of carnosine, α-lipoic acid and C/LA complex following MPTP administration normalized the total antioxidant activity in the brain tissue. Of all the compounds tested only C/LA complex normalized the metabolism of dopamine (DA) and serotonin (5-HT), while its components did not show similar effects when used separately. C/LA complex effectively restored the level of DA metabolites: the level of DOPAC was increased by 24.7â¯Â±â¯5.6% compared to the animals that had received MPTP only, and the level of HVA was restored to the values observed in the intact animals. Integral metabolic indices of DA (DOPAC/DA and HVA/DA ratios) and 5-HT turnover (5-HIAA/5-HT ratio) in the striatum tended to increase in case of C/LA complex administration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 95, June 2018, Pages 254-259
Journal: Regulatory Toxicology and Pharmacology - Volume 95, June 2018, Pages 254-259
نویسندگان
Olga I. Kulikova, Daniil S. Berezhnoy, Sergey L. Stvolinsky, Alexander V. Lopachev, Valentina S. Orlova, Tatiana N. Fedorova,