کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8552290 | 1562141 | 2018 | 27 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of Bisphenol-A on proliferation and expression of genes related to synthesis of polyamines, interferon tau and insulin-like growth factor 2 by ovine trophectoderm cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
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چکیده انگلیسی
This study evaluated the effects of bisphenol A (BPA) on proliferation of ovine trophectoderm (oTr1) cells, as well as expression of genes for transport of arginine and synthesis of polyamines. BPA reduced proliferation of oTr1 cells at concentrations of 1â¯Ãâ¯10â6, 1â¯Ãâ¯10â5, 1â¯Ãâ¯10â4â¯M compared to concentrations of 0, 1â¯Ãâ¯10â9, and 1â¯Ãâ¯10â8â¯M at 24 and 96â¯h of culture. Lower concentrations of BPA significantly increased expression of mRNAs for agmatinase (AGMAT), arginine decarboxylase (ADC), ornithine decarboxylase (ODC1) and solute carrier family 7 member 1 (SLC7A1). Similarly, synthesis of polyamines by oTr1 cells was greatest at lower concentrations of BPA and decreased as the dose of BPA increased. Expression of mRNAs for interferon tau (IFNT) and insulin-like growth factor 2 (IGF2) by oTr1 cells was greater than for controls at 1â¯Ãâ¯10â9â¯M BPA. Overall, the effects of BPA on proliferation and gene expression by oTr1 cells were highly dose-dependent.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 78, June 2018, Pages 90-96
Journal: Reproductive Toxicology - Volume 78, June 2018, Pages 90-96
نویسندگان
Mohammed A. Elmetwally, Amal A. Halawa, Yasser Y. Lenis, Wanjin Tang, Guoyao Wu, Fuller W. Bazer,