کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8552677 1562146 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genetic variation in low-dose effects of neonatal DES exposure in female rats
ترجمه فارسی عنوان
تنوع ژنتیکی در اثرات کم دوز نوردهی نوزاد نوزادان در موشهای صحرایی ماده
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
To confirm genetic variation in low-dose effects of diethylstilbestrol (DES), two inbred strains of rats, which have been selectively bred for high- and low-avoidance learning (HAA and LAA, respectively), were used in this study. LAA rats characteristically show later sexual maturation, earlier reproductive senescence, and lower body weight as compared to HAA rats. Female neonates of each strain were daily administered DES by oral gavage at doses of 0 (vehicle only), 0.05 and 0.5 μg/kg for the first 5 days after birth. As a result, early onset of abnormal estrous cycles was observed during the same period in HAA and LAA rats treated with 0.5 μg/kg. However, accelerated puberty and excessive body weight gains were observed only in LAA rats treated with 0.05 and 0.5 μg/kg. These results suggest that the effects of neonatal DES exposure vary with the genetic background of the female rats used.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 73, October 2017, Pages 322-327
نویسندگان
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