کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8553265 | 1562582 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
An in vitro cytotoxicities comparison of 16 priority polycyclic aromatic hydrocarbons in human pulmonary alveolar epithelial cells HPAEpiC
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
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چکیده انگلیسی
In present study, we compared for the first time the cytotoxicities of the 16 priority polycyclic aromatic hydrocarbons (PAHs) in human pulmonary alveolar epithelial cells HPAEpiC. Moreover, we examined the effects of each PAH on oxidative stress (SOD, GSH, and ROS), cell viability, extracellular LDH, and apoptosis. The 16 priority PAHs were classified into four levels of cytotoxicity: (1) high cytotoxicity, BkF, BaP, and DBA; (2) moderate cytotoxicity, BbF, IND, BghiP, BaA, and CHR; (3) low cytotoxicity, PA, FL, and Pyr; and (4) mild cytotoxicity, Nap, AcPy, Acp, Flu, and Ant. Most of the PAHs showed benzene-ring-related cytotoxicity, except PA with 3-ring structure, cytotoxicity of which is similar to those of FL and Pyr with 4-ring structure. Results indicated the need for more studies on DBA, IND, and BghiP, among others, which are rarely investigated. PA, FL, and Pyr with little carcinogenicity should also be evaluated. This study will provide useful references for studies on the effects of PAHs on different cells or animal models.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 290, 15 June 2018, Pages 10-18
Journal: Toxicology Letters - Volume 290, 15 June 2018, Pages 10-18
نویسندگان
Shaorui Ke, Qi Liu, Yuhan Yao, Xinlian Zhang, Guodong Sui,