کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8553358 | 1562584 | 2018 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hexamoll® DINCH: Lack of in vivo evidence for obesogenic properties
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کلمات کلیدی
ERODCHDAPRODMEHPSVFOPLS-DAethoxyresorufin-O-deethylaseDEHPPPARALTGGTCyPdi-(2-ethylhexyl) phthalate - di- (2-اتیل هگزیل) فتالاتmono-(2-ethylhexyl) phthalate - mono (2-ethylhexyl) phthalateAST - آسپارتات ترانس آمینازAspartate aminotransferase - آسپارتات ترانس آمیناز یا AST Alanine aminotransferase - آلانین آمینوترانسفرازALP - آلکالن فسفاتازAlkaline phosphatase - آلکالین فسفاتاز یا فسفاتاز قلیاییBROD - برادToxicokinetics - تاکسیکوسینتیک، تاکسیکوکینتیکcytochrome P - سیتوکروم پbody mass index - شاخص توده بدنBMI - شاخص توده بدنیMetabolome - متابولومObesogen - چاق کنندهStromal vascular fraction - کسر عروق استروماgamma glutamyl transferase - گاما گلوتامیل ترانسفرازperoxisome proliferator-activated receptor - گیرنده فعال فعال پروکسیوم
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Hexamoll® DINCH is an important alternative to phthalate plasticizers. Although regulatory reviews have not identified any potential hazards even in sensitive populations, an in vitro study by Campioli et al. (2015) suggested Hexamoll® DINCH might alter fat storage in adipocytes resulting in obesity. To evaluate this hypothesis, data from studies with Hexamoll® DINCH were reviewed for evidence of deposition in fat, changes in body weight, or changes in serum chemistry reflecting altered metabolic status. Body weights of F1 and F2 pups in a two-generation study did not differ from controls even at 1000â¯mg Hexamoll® DINCH/kg body weight. Mean relative liver weights from the 1000 and 300â¯mg/kg bw groups were increased, but without histopathologic changes. Triglyceride and cholesterol levels in serum were not affected. In addition, subchronic and chronic studies in rats did not give evidence of an obesogenic effect. Radioactivity from 20 or 1000â¯mg/kg bw 14C-labelled Hexamoll® DINCH dosed orally remained 2-3 times longer in adipose tissue than in well-perfused tissues; however, levels were 20-500% below other tissues at 1 and 8â¯h post dosing. Radioactivity concentrations in organs and tissues excluding the GI tract declined rapidly and continuously, and decreased in parallel to the concentration in plasma during the following 20â¯h. Both, initial and terminal half-lives of radioactivity concentration do not indicate a potential for accumulation. Furthermore, a metabolomic comparison of Hexamoll® DINCH with DEHP and other phthalates shows complete separation of the metabolomic profile of these two chemical classes, meaning that their effects on the body and the body's reaction to the substance are different. Hence, comprehensive in vivo data do not show any evidence of Hexamoll® DINCH altering fat metabolism or having obesogenic properties.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 288, 15 May 2018, Pages 99-110
Journal: Toxicology Letters - Volume 288, 15 May 2018, Pages 99-110
نویسندگان
Angelika Langsch, Raymond M. David, Steffen Schneider, Saskia Sperber, Volker Haake, Hennicke Kamp, Edgar Leibold, Bennard van Ravenzwaay, Rainer Otter,