PINK1/Parkin-mediated mitophagy was activated against 1,4-Benzoquinone-induced apoptosis in HL-60 cells

A proposed model of molecular iteraction to delineate the actin mechanisms of 1,4-benzoquinone in HL60 cell. 1,4-benzoquinone, a metabolite of benzene, decreases mitochondrial membrane potential (MMP), increases in reactive oxygen species (ROS), and activates the PINK1/Parkin pathway mitophagy that plays a protective role in apoptosis.