کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8625664 | 1568227 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Organ regeneration based on developmental biology: past and future
ترجمه فارسی عنوان
بازسازی ارگان بر اساس زیست شناسی توسعه: گذشته و آینده
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
چکیده انگلیسی
In this decade, great progress has been made in the field of organ regeneration by incorporating emerging concepts from the fields of stem cell biology and developmental biology, and this progress has pioneered a new frontier in regenerative medicine. The generation of bioengineered organ germ-utilizing, fate-determined, organ-inductive epithelial and mesenchymal cells has provided evidence for the concept of functional organ regeneration in vivo. Organoid studies have verified that nearly all organs can be generated in the form of a mini-organ by recapitulating embryonic body patterning and establishing an organ-forming field among self-organizing pluripotent stem cells by utilizing cytokines that mimic the patterning and positional signals of organogenesis. More recently, the regeneration of an integumentary organ system composed of multiple organs, including hair follicles, has been achieved, demonstrating that regenerative medicine is forthcoming. In this review, we will introduce current research trends aimed at regenerating a functional three-dimensional (3D) organ, and we will discuss the potential use of these recent achievements and future directions needed to realize the next-generation of regenerative therapy for organ replacement.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Genetics & Development - Volume 52, October 2018, Pages 42-47
Journal: Current Opinion in Genetics & Development - Volume 52, October 2018, Pages 42-47
نویسندگان
Makoto Takeo, Takashi Tsuji,