کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8625943 1568231 2018 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Eukaryotic initiation factor 4F - sidestepping resistance mechanisms arising from expression heterogeneity
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Eukaryotic initiation factor 4F - sidestepping resistance mechanisms arising from expression heterogeneity
چکیده انگلیسی
There is enormous diversity in the genetic makeup and gene expression profiles between and within tumors. This heterogeneity leads to phenotypic variation and is a major mechanism of resistance to molecular targeted therapies. Here we describe a conceptual framework for targeting eukaryotic initiation factor (eIF) 4F in cancer - an essential complex that drives and promotes multiple Cancer Hallmarks. The unique nature of eIF4F and its druggability bypasses several of the heterogeneity issues that plague molecular targeted drugs developed for cancer therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Genetics & Development - Volume 48, February 2018, Pages 89-96
نویسندگان
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