کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8630653 | 1568841 | 2018 | 74 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The first multi-zoo application of an allostatic load index to western lowland gorillas (Gorilla gorilla gorilla)
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کلمات کلیدی
ACTHAllostasisIL-6DHEA-STSHSRFHDLCRHTRFhigh-density lipoprotein - HDL یا لیپوپروتئین با دانسیته بالا یا چگالی بالاPhysiological dysregulation - اختلال فیزیولوژیکیStress - استرس یا فشار روانیinterleukin-6 - اینترلوکین ۶cardiovascular disease - بیماری قلب و عروقیTriiodothyronine - تری یدوتیرونینtumor necrosis factor alpha - تومور نکروز عامل آلفاthyroxine - تیروکسینCVD - رسوب دهی شیمیایی بخار Captivity - زندانHealth - سلامتیTNF-α - فاکتور نکروز توموری آلفاHPA - میلی بار یا هکتوپاسکالcorticotropin releasing hormone - هورمون آزاد کننده کورتیکوتروپینC-reactive protein - پروتئین واکنشی سیCRP - پروتئین واکنشی سی یا سی. آر. پی Nonhuman primate - پریمات غیر انسانی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Vertebrate stress responses are highly adaptive biological functions, maximizing survival probability in life-threatening situations. However, experiencing repeated and/or chronic stressors can generate physiological dysregulation and lead to disease. Because stress responses are multi-systemic and involve a wide range of physiological functions, identifying responses to stressors is best accomplished using integrated biomarker models. Allostatic load, defined as the physiological dysregulation that accumulates over the lifespan due to stressful experiences, is one such model. Allostatic load is measured using allostatic load indices, which are composites of biomarkers from multiple somatic systems. Previously, we reported the use of a 7-biomarker allostatic load index (albumin, CRH, cortisol, DHEA-S, glucose, IL-6, TNF-α) in western lowland gorillas housed at a single zoo. Herein, this index is expanded to examine allostatic load responses to lifetime stressors in gorillas from two additional zoos (nâ¯=â¯63) as well as two pooled samples. The index was created using quartile cut-points for each biomarker. Significant associations were observed between multiple predictor variables and allostatic load, including sex, age, number of stressful events (anesthetic events, zoo transfers, agonistic interactions with wounding, pregnancies), and rearing history (mother-reared, nursery-reared, wild-caught). Additionally, allostatic load was associated with indicators of morbidity (creatinine, cholesterol, triglycerides), age at death, and mortality risk. These results are consistent with those reported in human allostatic load research, suggesting allostatic load indices have potential as an investigative and clinical tool for gorillas and other great apes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: General and Comparative Endocrinology - Volume 266, 15 September 2018, Pages 135-149
Journal: General and Comparative Endocrinology - Volume 266, 15 September 2018, Pages 135-149
نویسندگان
Ashley N. Edes, Barbara A. Wolfe, Douglas E. Crews,