کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8633987 | 1569088 | 2018 | 43 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Protective effect of supplementation with biotin against high-fructose-induced metabolic syndrome in rats
ترجمه فارسی عنوان
اثر محافظتی مکمل با بیوتین در برابر سندرم متابولیک ناشی از فروکتوز در موش صحرایی
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کلمات کلیدی
PBSSBPTBAHDLALTTBARShigh-density lipoprotein - HDL یا لیپوپروتئین با دانسیته بالا یا چگالی بالاAST - آسپارتات ترانس آمینازAspartate aminotransferase - آسپارتات ترانس آمیناز یا AST Alanine aminotransferase - آلانین آمینوترانسفرازThiobarbituric acid - اسید تیوباربیتوریکBiotin - بیوتین، ویتامین B7،فاکتور W، کوآنزیم R، ویتامین HIntraperitoneally - داخل صفاقیHigh-fructose diet - رژیم غذایی فروکتوزMetabolic syndrome - سندرم متابولیکsystolic blood pressure - فشار خون سیستولیکphenylephrine - فنیل آفرینlactate dehydrogenase - لاکتات دهیدروژناز LDH - لاکتات دهیدروژناز به صورت مختصر شده LDH Low-density lipoprotein - لیپوپروتئین کم چگالی یا الدیال LDL - لیپوپروتئین کم چگالی(کلسترول بد)Phosphate-buffered saline - محلول نمک فسفات با خاصیت بافریthiobarbituric acid-reactive substances - مواد واکنش پذیر اسید تیوباربیتوریکRats - موش صحرایی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
چکیده انگلیسی
Several reports have demonstrated that pharmacological concentrations of biotin reduce hyperglycemia, hypertriglyceridemia, and hypertension. We hypothesized that biotin could exert a protective effect on some illness-associated metabolic syndrome. To test this hypothesis, male Wistar rats were fed a diet containing 30% fructose in drinking water and classified into four groups: C, the control group; B, the group receiving biotin (intraperitoneal injection, 2 mg/kg); F, the group receiving fructose (30% w/v); and FB, the group receiving fructose-biotin. The administration of biotin began after the rats had been on a high-fructose diet for 12 weeks and continued for 4 weeks. Our results showed that food and fluid intake were diminished in the F and FB groups. However, the final body weights were similar between the groups. A significant increase in hepatic triglyceride and cholesterol content, plasma cholesterol, triglycerides, transaminases, low-density lipoprotein cholesterol (LDL-c), systolic blood pressure, and vasocontraction, as well as a decrease in high-density lipoprotein cholesterol (HDL-c) were observed in the F group. Glucose tolerance and insulin tolerance were also impaired in the F group. The administration of biotin ameliorated all these changes. Hepatic oxidative stress as well as macrovesicular fatty changes in hepatocytes caused by a high-fructose diet were also improved by biotin. Our findings demonstrate that biotin has a protective role against metabolic syndrome by improving insulin resistance associated with normal hepatic and serum levels of triglyceride and cholesterol, blood pressure, and the prevention of steatosis and hepatic oxidative damage. Therefore, biotin could be used as a therapeutic strategy in the pharmacological treatment of metabolic syndrome.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition Research - Volume 57, September 2018, Pages 86-96
Journal: Nutrition Research - Volume 57, September 2018, Pages 86-96
نویسندگان
Asdrubal Aguilera-Mendez, MarÃa G. Hernández-Equihua, Alfonso C. Rueda-Rocha, Clotilde Guajardo-López, Renato Nieto-Aguilar, Deyanira Serrato-Ochoa, León F. RuÃz Herrera, José A. Guzmán-Nateras,