کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8634001 | 1569089 | 2018 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The “T” allele of apolipoprotein A5 rs2075291 is significantly associated with higher total cholesterol and triglyceride and lower high-density lipoprotein cholesterol levels in Asians: a meta-analysis
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کلمات کلیدی
CHDAPOA5 geneAPOA5EWASSMDSTROBEHDL-CPRISMALDL-CHWE95% CI - 95٪ CIApolipoprotein A5 - آپولیپوپروتئین A5Preferred Reporting Items for Systematic reviews and Meta-analysis - آیتم های گزارش مورد نظر برای بررسی های متداول و متا آنالیزcoronary heart disease - بیماری عروق کرونر قلبTriglycerides - تریگلیسریدHardy–Weinberg equilibrium - تعادل هاردی-وینبرگstandardized mean difference - تفاوت میانگین استاندارد شدهSTREGA - جادوگرAsian population - جمعیت آسیاPCR-RFLP - روش PCR-RFLPLipid levels - سطوح لیپید95% confidence interval - فاصله اطمینان 95٪Meta-analysis - فرا تحلیل high-density lipoprotein cholesterol - لیپوپروتئین پرچگالی یا اچدیالGenome-wide association study - مطالعه مرتبط با ژنومGWAS - مطالعهٔ همخوانی سراسر ژنومtotal cholesterol - کلسترول تامLow-density lipoprotein cholesterol - کلسترول لیپوپروتئین با چگالی کم
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Previous studies have discussed the association between apolipoprotein A5 (APOA5) gene rs2075291 polymorphism and lipid levels, but the results were inconsistent. The meta-analysis was performed to evaluate the reported effects of rs2075291 polymorphism on blood lipid levels, including total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in Asians. A literature search was performed in six databases from January 1, 2001 to March 1, 2017. A standardized mean difference (SMD) with 95% confidence interval (95% CI) was computed to estimate the effect value. Overall, 10 articles with 19 reports were included and most of them were from Chinese institutions. Pooled results indicated significant effects of rs2075291 on lipid levels in Asians; the carriers of T allele had higher TC and TG levels but lower HDL-C level than the non-carriers, and the corresponding SMD (95% CI) were 0.20 (0.04â0.36), 0.74 (0.54â0.94), and â0.17 (â0.33 to â0.00), respectively. No significant difference was found for the LDL-C level: P = .172. Although results from the meta-analysis suggest that the T allele of the APOA5 rs2075291 is associated with higher TC and TG levels and lower HDL-C levels, large-scale studies considering the gene-gene and gene-environment interaction are needed to further explore the effects of rs2075291 polymorphism on blood lipid levels in different ethnicities.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition Research - Volume 56, August 2018, Pages 11-22
Journal: Nutrition Research - Volume 56, August 2018, Pages 11-22
نویسندگان
Xinling Qian, Yuqian Li, Xiaotian Liu, Linlin Li, Kaili Yang, Ruihua Liu, Honglei Zhang, Yuanyuan Shi, Fei Yu, Zhenxing Mao, Ronghai Bie, Chongjian Wang,