Reproducible and reliable general semiquantitative food frequency questionnaire for evaluating iodine intake in Chinese children

Iodine deficiency is a global issue that is correlated with a variety of diseases and can affect individuals of all ages. We hypothesized that a general, semiquantitative food frequency questionnaire (FFQ) could be a valuable tool to evaluate iodine intake in children. Study participants comprised 687 healthy children between the ages of 7 and 13 years. The FFQ was developed to assess habitual iodine intake over a 6-month period (FFQ1). A 3-day estimated food diary (3DEFD) and the habitual daily iodine intake, calculated from 2-repeated 24-hour urine iodine excretion, tested the intermethod relative validity of the FFQ. There were 92 children who also repeated the FFQ (FFQ2) 3 weeks later to assess for FFQ reproducibility. Iodine intake estimated by FFQ1 + water was significantly higher than that indicated by the 3DEFD + water (204 μg/d vs 156 μg/d, P < .001), whereas there were no differences between habitual daily iodine intake and FFQ1 + water (185 μg/d vs 204 μg/d, P = .223). The interclass correlation coefficients of iodine intake estimated by the FFQ1 and FFQ2 were 0.72 (P < .001). The FFQ1 + water was moderately correlated with the 3DEFD + water (Spearman correlation coefficient = 0.57, P < .001) as well as habitual daily iodine intake (SCC = 0.34, P < .001). The subjects classified into the same or adjacent quartiles ranged from 32% to 93%. The κ value α was 0.46 for FFQ1 and FFQ2 (P < .001) 0.27 for FFQ1 + water and 3DEFD + water (P < .001), and 0.09 for FFQ1 + water and habitual daily iodine intake (P < .001). The results showed this FFQ is a reliable and reproducible tool in evaluating iodine intake in Chinese children.