کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8634416 | 1569099 | 2017 | 31 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Higher intake of fish and fat is associated with lower plasma s-adenosylhomocysteine: a cross-sectional study
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
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چکیده انگلیسی
Several B-vitamins act as co-factors in one-carbon metabolism, a pathway that plays a central role in several chronic diseases. However, there is a lack of knowledge of how diet affects markers in one-carbon metabolism. The aim of this study was to explore dietary patterns and components associated with one-carbon metabolites. We hypothesized that intake of whole-grains and fish would be associated with lower Hcy, and higher SAM:SAH ratio due to their nutrient content. We assessed dietary information using a four-day dietary record in 118 men and women with features of the metabolic syndrome. In addition we assessed whole-blood fatty acid composition and plasma alkylresorcinols. Plasma s-adenosylmethionine (SAM), s-adenosylhomocysteine (SAH), homocysteine (Hcy) and vitamin B12 was included as one-carbon metabolism markers. We used principal component analysis (PCA) to explore dietary patterns and multiple linear regression models to examine associations between dietary factors and one-carbon metabolites. PCA separated subjects based on prudent and unhealthy dietary patterns, but the dietary pattern score was not related to the one-carbon metabolites. Whole grain intake was found to be inversely associated to plasma Hcy (â4.7% (â9.3; 0.0), PÂ =Â .05) and total grain intake tended to be positively associated with SAM and SAH (2.4% (â0.5; 5.5), PÂ =Â .08; 5.8% (â0.2; 12.1), PÂ =Â .06, respectively, per SD increase in cereal intake). Fish intake was inversely associated with plasma Hcy and SAH concentrations (â5.4% (â9.7; â0.8), PÂ =Â .02 and â7.0% (â12.1; â1.5), PÂ =Â .01, respectively) and positively associated with the SAM:SAH ratio (6.2% (1.6; 11.0), PÂ =Â .008). In conclusion, intake and fish and whole-grain appear to be associated with a beneficial one-carbon metabolism profile. This indicates that dietary components could play a role in regulation of one-carbon metabolism with a potential impact on disease prevention.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition Research - Volume 46, October 2017, Pages 78-87
Journal: Nutrition Research - Volume 46, October 2017, Pages 78-87
نویسندگان
Mads V. Lind, Lotte Lauritzen, Oluf Pedersen, Henrik Vestergaard, Ken D. Stark, Torben Hansen, Alastair B. Ross, Mette Kristensen,