کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8645060 | 1569774 | 2018 | 25 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of exercise training on adipose tissue apelin expression in streptozotocin-nicotinamide induced diabetic rats
ترجمه فارسی عنوان
تأثیر تمرینات ورزشی بر بیان آپینین بافت چربی در موشهای صحرایی دیابتی ناشی از استرپتوزوتوسین-نیکوتین آمید
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کلمات کلیدی
STZ(i.p.)T2DMLDL-CHOMA-IRHDLAUC - AUCIPGTT - IPGTAdipokine - آدپیکینintraperitoneal glucose tolerance test - آزمون تحمل گلوکز داخل صفاقیhomeostasis model assessment of insulin resistance - ارزیابی مدل هومیوستاز مقاومت به انسولینstreptozotocin - استرپتوزوتوسینvisceral adipose tissue - بافت چربی درشتanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancetriglyceride - تریگلیسریدAerobic exercise - تمرین هوازی، تمرین ایروبیکintraperitoneal - داخل صفاقیApelin - درخواستType 2 diabetes - دیابت نوع 2Type 2 diabetes mellitus - دیابت نوع دوarea under the curve - منطقه تحت منحنیNicotinamide - نیکوتینامید، نیاسینامیدtotal cholesterol - کلسترول تامHigh-density lipoprotein-cholesterol - کلسترول لیپوپروتئین با چگالی بالاLow-density lipoprotein-cholesterol - کلسترول لیپوپروتئین با چگالی کم
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
چکیده انگلیسی
Apelin is an adipocyte-derived peptide that plays an important role in regulation of energy homoeostasis and decrease of insulin resistance. We investigated the effects of exercise training on adipose tissue apelin expression in streptozotocin-nicotinamide induced diabetic rats. In this experimental study, 38 male Wistar rats were assigned to 4 groups: sedentary non-diabetic, trained non-diabetic, sedentary diabetic and trained diabetic. Type 2 diabetes mellitus (T2DM) was induced by intraperitoneal injection of streptozotocin and nicotinamide in adult rats. The trained groups ran 8-week on treadmill progressively for 45â¯min at a speed of 24â¯m/min and a 5% grade. After the training period, an intraperitoneal glucose tolerance test was performed in addition to the measurement of blood lipids and plasma apelin levels. Apelin mRNA levels in visceral adipose tissue were also analyzed. Two-way repeated measures analysis of variance (ANOVA) and Pearson correlation coefficient was used for analyzing data. Pâ¯<â¯0.05 was considered to be statistically significant. Results indicated a significant decrease of insulin resistance followed by a significant increase of plasma levels and mRNA expression of apelin in trained diabetic compared with sedentary diabetic rats. Furthermore, apelin levels did not correlate significantly with body weight and epididymal fat weight in trained diabetic rats. In conclusion, the findings revealed that chronic exercise training, independently of body weight and fat pad weight by decrease of insulin resistance can increase apelin levels in visceral adipose tissue, thereby attenuating the progression of diabetes and decreasing insulin resistance in T2DM rats.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 662, 1 July 2018, Pages 97-102
Journal: Gene - Volume 662, 1 July 2018, Pages 97-102
نویسندگان
Fahimeh Kazemi, Saleh Zahediasl,