Vitamin D receptor Fok1 polymorphism and its relationship with premenstrual syndrome

We observed a significant association between VDR FokI polymorphism and PMS. However, on subgroup analysis by ethnicity, the FF genotype was more predominant among Arab women. ff mutation was associated with a significantly higher risk for PMS [OR = 3.72, 95% CI = 1.65-8.35, p ≤0.05] among non-Arabs.