Computational analysis of non-synonymous SNPs in bovine Mx1 gene

The Mx gene encodes an antiviral protein and is induced by type 1 interferons (IFNs). In this study, bovine Mx1B gene was analysed using six online tools to evaluate the effect of single nucleotide polymorphisms (SNPs) that may cause some deleterious effect in the animal. Out of 115 nsSNPs evaluated, 23nsSNPs were classified as highly damaging. The results of computational analysis of the Mx1 gene further widens the scope of research on mutations that can be prioritized in future population and laboratory studies.