کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8646364 | 1570094 | 2017 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Limitations of the Mycobacterium tuberculosis reference genome H37Rv in the detection of virulence-related loci
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کلمات کلیدی
NADPORFPPEH37RvCFP-10ESAT-6phthiocerol dimycocerosatePDIMESX-1HGCWhole genome sequencing - توالی یابی کامل ژنومopen-reading frame - قاب خواندن بازMycobacterium tuberculosis - مایکوباکتریوم توبرکلوزیسMolybdopterin cofactor - مفاصل مولیبدپترینMoco - موکوnicotinamide adenine dinucleotide phosphate - نیکوتین آمید adenine dinucleotide phosphate
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The genome sequence of Mycobacterium tuberculosis strain H37Rv is an important and valuable reference point in the study of M. tuberculosis phylogeny, molecular epidemiology, and drug-resistance mutations. However, it is becoming apparent that use of H37Rv as a sole reference genome in analysing clinical isolates presents some limitations to fully investigating M. tuberculosis virulence. Here, we examine the presence of single locus variants and the absence of entire genes in H37Rv with respect to strains that are responsible for cases and outbreaks of tuberculosis. We discuss how these polymorphisms may affect phenotypic properties of H37Rv including pathogenicity. Based on our observations and those of other researchers, we propose that use of a single reference genome, H37Rv, is not sufficient for the detection and characterisation of M. tuberculosis virulence-related loci. We recommend incorporation of genome sequences of other reference strains, in particular, direct clinical isolates, in such analyses in addition to H37Rv.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Genomics - Volume 109, Issues 5â6, October 2017, Pages 471-474
Journal: Genomics - Volume 109, Issues 5â6, October 2017, Pages 471-474
نویسندگان
Ronan F. O'Toole, Sanjay S. Gautam,