کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8646448 | 1570129 | 2017 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
OrthoGNC: A Software for Accurate Identification of Orthologs Based on Gene Neighborhood Conservation
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: OrthoGNC: A Software for Accurate Identification of Orthologs Based on Gene Neighborhood Conservation OrthoGNC: A Software for Accurate Identification of Orthologs Based on Gene Neighborhood Conservation](/preview/png/8646448.png)
چکیده انگلیسی
Orthology relations can be used to transfer annotations from one gene (or protein) to another. Hence, detecting orthology relations has become an important task in the post-genomic era. Various genomic events, such as duplication and horizontal gene transfer, can cause erroneous assignment of orthology relations. In closely-related species, gene neighborhood information can be used to resolve many ambiguities in orthology inference. Here we present OrthoGNC, a software for accurately predicting pairwise orthology relations based on gene neighborhood conservation. Analyses on simulated and real data reveal the high accuracy of OrthoGNC. In addition to orthology detection, OrthoGNC can be employed to investigate the conservation of genomic context among potential orthologs detected by other methods. OrthoGNC is freely available online at http://bs.ipm.ir/softwares/orthognc and http://tinyurl.com/orthoGNC.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Genomics, Proteomics & Bioinformatics - Volume 15, Issue 6, December 2017, Pages 361-370
Journal: Genomics, Proteomics & Bioinformatics - Volume 15, Issue 6, December 2017, Pages 361-370
نویسندگان
Soheil Jahangiri-Tazehkand, Limsoon Wong, Changiz Eslahchi,