A possible role of impaired cell-mediated immunity in the pathogenesis of tumefactive demyelinating lesions

- An impaired cell-mediated immunity is common in tumefactive demyelinating lesions.
- An impaired cell-mediated response to pathogens could lead to their persistence.
- Persistence of noxa pathogena stimulates a compensatory innate immune response.
- Immunothrombosis is a procoagulant innate immune mechanism against pathogens.
- Immunothrombosis might be at the basis of the tumefactive demyelinating lesions.