کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8675247 | 1578920 | 2018 | 40 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Selection of P2Y12 Inhibitor in Percutaneous Coronary Intervention and/or Acute Coronary Syndrome
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کلمات کلیدی
ST-segment elevation MIP2Y12 inhibitorHPRCyPACSNSTEMICOX-1MACEDAPTTIASTEMIPCIAcuity - آفتابAntiplatelet therapy - آنتی بادی درمانMyocardial infarction - آنفارکتوس میوکاردcoronary artery disease - بیماری عروق کرونرMyocardial infraction - تخلف از قلبticagrelor - تیکاگرلورCABG - جراحی کنارگذر سرخرگ تاجیtransient ischemic attack - حمله ایسکمی گذراmajor adverse cardiovascular events - حوادث مهم قلبی عروقی معیوبdual antiplatelet therapy - درمان ضد تهاجمی دوگانهLoading dose - دوز بارگیریAcute coronary syndrome - سندرم کرونری حادcytochrome - سیتوکرومcyclooxygenase-1 - سیکلوکوکسیژناز 1CAD - طراحی به کمک رایانه یا کَدpercutaneous coronary intervention - مداخله کرونری از راه پوستhazard ratio - نسبت خطرMaintenance dose - نگهداری دزPrasugrel - پراسوگرلPlatelets - پلاکت هاCoronary artery bypass graft - پیوند عروق کرونرcangrelor - کانگرلورclopidogrel - کلوپیدوگرلGUSTO - گوستو
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
The P2Y12 receptor plays a critical role in the amplification of platelet aggregation in response to various agonists and stable thrombus generation at the site of vascular injury leading to deleterious ischemic complications. Therefore, treatment with a P2Y12 receptor blocker is a major effective strategy to prevent ischemic complications in high-risk patients with acute coronary syndrome (ACS) and patients undergoing percutaneous coronary intervention (PCI). The determination of optimal platelet inhibition is based on maximizing antithrombotic properties while minimizing bleeding risk and is critically dependent on individual patient's propensity for thrombotic and bleeding risks. Immediately after ACS and during PCI, where highly elevated thrombotic activity is present, a loading dose administration with a potent P2Y12 receptor blocker such as ticagrelor or prasugrel is preferred. In stable coronary artery disease patients undergoing PCI, clopidogrel is widely used. In addition, in patients with ST-segment elevation myocardial infraction who cannot take oral medications, a fast acting intravenous glycoprotein IIb/IIIa inhibitor or P2Y12 receptor blocker, cangrelor, may add clinical benefits. During long term therapy, a strategy that prevents ischemic risk while avoiding excessive bleeding risk is similarly desired. Although up to one year dual antiplatelet therapy (DAPT) is recommended in patients undergoing elective stenting, the available data support the anti-ischemic benefit of prolonged DAPT (more than1 year) in patients with prior MI. In addition to the DAPT risk calculator tool, future risk assessment methods that analyze intrinsic thrombogenicity and atherosclerotic coronary burden may further identify the optimal candidate for prolonged DAPT to improve net clinical outcomes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Cardiovascular Diseases - Volume 60, Issues 4â5, JanuaryâFebruary 2018, Pages 460-470
Journal: Progress in Cardiovascular Diseases - Volume 60, Issues 4â5, JanuaryâFebruary 2018, Pages 460-470
نویسندگان
Udaya S. Tantry, Eliano P. Navarese, Aung Myat, Paul A. Gurbel,