کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8679441 | 1579178 | 2018 | 36 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Role of plasminogen activator inhibitor-1 in coronary pathophysiology
ترجمه فارسی عنوان
نقش بازدارنده فعال کننده پلاسمینوژن 1 در پاتوفیزیولوژی کرونر
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کلمات کلیدی
مهارکننده فعال کننده پلاسمینوژن -1، بیماری عروق کرونر، مداخله عروق کرونر بیومارکر، ترومبوز استنت استنت درون استنت،
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی
The standard of care for obstructive atherosclerotic coronary disease is revascularization, predominantly achieved via percutaneous placement of a stent with concurrent medical therapy. Advancements in percutaneous coronary intervention (PCI) have dramatically improved outcomes. However, major complications from PCI due to target lesion failure continue to occur at rates between 5 and 10% in the first twelve months following intervention limiting its therapeutic efficacy. Plasminogen activator inhibitor-1 (PAI-1) is a protein of interest for both arterial remodeling and thrombotic risk as it regulates cell migration and vascular thrombosis. Elevated PAI-1 antigen levels have been identified as a potential biomarker for coronary artery disease and metabolic syndrome while being modulated by a number of atherosclerotic risk factors. Although linked by some studies as a marker of disease severity and prognosis, it remains to be understood whether it is also a mediator and/or therapeutic target of vascular disease. In this review, we discuss the current understanding of PAI-1 in vascular disease and its potential role in in-stent restenosis and stent thrombosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Thrombosis Research - Volume 164, April 2018, Pages 54-62
Journal: Thrombosis Research - Volume 164, April 2018, Pages 54-62
نویسندگان
Richard G. Jung, Trevor Simard, Alisha Labinaz, F. Daniel Ramirez, Pietro Di Santo, Pouya Motazedian, Rebecca Rochman, Chantal Gaudet, Mohammad Ali Faraz, Rob S.B. Beanlands, Benjamin Hibbert,