Altered thalamic glucose metabolism in cerebellar projections in Parkinson's disease

Hence our results support a critical (maybe compensatory) role of the Cb-thalamic projections and forces a more straightforward thinking away from a pure “symptom-oriented” to a “dynamic-circuitry” approach due to functional changes in glucose metabolism with Cb and BG as one of the circuitry key elements defining the clinical parkinsonian phenotype.