کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8683686 | 1579811 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Brain network alteration in patients with temporal lobe epilepsy with cognitive impairment
ترجمه فارسی عنوان
تغییر دنده مغز در بیماران مبتلا به صرع لوب تمپورال با اختلال شناختی
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کلمات کلیدی
IPCVBMRSNDMNSMNECNMVNDLPFCTLEICAICSvmPFCCNIMoCASEEGStereotactic electroencephalographysupplementary motor areasVSNCorpus callosumSPMBOLDPFCPCCSLFMDLFWHMGLMFunctional connectivity - اتصال عملکردی independent components - اجزای مستقلcognitive impairment - اختلال شناختیMontreal Cognitive Assessment - ارزیابی شناختی مونترالResting state network - استراحت شبکه ایالتElectroencephalography - الکتروانسافالوگرافیReST - باقی ماندهMEG - بهIndependent component analysis - تجزیه و تحلیل جزء مستقلframewise displacement - جابجایی چارچوبMinimum Description Length - حداقل طول شرحSMA - دبیرستانdefault mode network - شبکه حالت پیش فرضVisual network - شبکه ویژوالExecutive control network - شبکه کنترل اجراییtemporal lobe epilepsy - صرع لوب تمپورالfull width at half maximum - عرض کامل در نیمی از حداکثرCognitive function - عملکرد شناختیsuperior longitudinal fasciculus - فسیکولوس طولی طولانی ترprefrontal cortex - قشر prefrontalposterior cingulate cortex - قشر ساقه خلفیInferior parietal cortex - قشر نای پایین ترdorsolateral prefrontal cortex - قشر پیشانی غدد درون رحمیmean diffusivity - متوسط نفوذپذیریGeneral linear model - مدل خطی کلیmagnetoencephalography - مغناطیس مغزvoxel-based morphometry - مورفومتری مبتنی بر واکسلfractional anisotropy - ناپیوستگی کسریStatistical Parametric Mapping - نقشه برداری پارامترهای آماریEEG - نوار مغزیblood oxygen level-dependent - وابسته به سطح اکسیژن خونhealthy control - کنترل سالمventromedial prefrontal cortex - کورتکس prefrontal ventromedial
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
The aims of this study were to investigate the brain network alternation in patients with temporal lobe epilepsy (TLE) with and without cognitive impairment (CI) using functional magnetic resonance imaging (fMRI) and to further explore the potential mechanisms of epilepsy-induced CI. Forty patients with TLE and nineteen healthy controls (HCs) were recruited for this study. All participants received the Montreal Cognitive Assessment (MoCA) test, and the patients were divided into CI (n = 21) and cognitive nonimpairment (CNI) groups (n = 19) according to MoCA performance. Functional connectivity (FC) differences of resting state networks (RSNs) were compared among the CI, CNI, and HC groups. Correlation between FC and MoCA scores was also observed. When compared with the HC group, significantly decreased FC between medial visual network (mVN) and left frontoparietal network (lFPN) as well as between visuospatial network (VSN) and the anterior default mode network (aDMN) were revealed in both CI and CNI groups. In addition, significantly decreased FC between lFPN and executive control network (ECN) and increased FC between ECN and sensorimotor-related network (SMN) were found in CNI and CI groups, respectively. When compared with the CNI group, the CI group exhibited significant increased FC between ECN and lFPN as well as between ECN and SMN. Moreover, in the CI group, FC between ECN and lFPN showed negative correlation with attention scores. Our findings suggested that cognitive networks are different from epileptic networks, and the increased FC between RSNs closely related to cognitive function changes may help us to further understand the mechanism of CI in TLE.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy & Behavior - Volume 81, April 2018, Pages 41-48
Journal: Epilepsy & Behavior - Volume 81, April 2018, Pages 41-48
نویسندگان
Hongyu Yang, Chao Zhang, Chang Liu, Tao Yu, Guojun Zhang, Nan Chen, Kuncheng Li,