کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8683775 | 1579813 | 2018 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Intense olfactory stimulation blocks seizures in an experimental model of epilepsy
ترجمه فارسی عنوان
تشنج بویایی شدید باعث تشنج در یک مدل آزمایشی صرع می شود
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کلمات کلیدی
TMT2,5-Dihydro-2,4,5-trimethylthiazolineTCVPTZWistar audiogenic ratCSINMDAN-methyl-d-aspartateTOLsaline groupTLESAL - WILLχ2 - x2Chi-square test - آزمون Chi-SquareElectroencephalogram - الکتروانسفالوگرافیOlfactory stimulation - تحریک بویاییLimbic seizures - تشنج لنفاویToluene - تولوئنseconds - ثانیهWar - جنگstandard error of the mean - خطای استاندارد میانگینSaline - سالینCentimeters - سانتیمترAudiogenic kindling - سوزش گوش دادنSound - صداtemporal lobe epilepsy - صرع لوب تمپورالNeuroethology - عصب شناسیpre - قبل ازSEM - مدل معادلات ساختاری / میکروسکوپ الکترونی روبشیEEG - نوار مغزیWild running - وحشی در حال اجراpost - پستpentylenetetrazol - پنتیلن تترازول
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
There are reports of patients whose epileptic seizures are prevented by means of olfactory stimulation. Similar findings were described in animal models of epilepsy, such as the electrical kindling of amygdala, where olfactory stimulation with toluene (TOL) suppressed seizures in most rats, even when the stimuli were 20% above the threshold to evoke seizures in already kindled animals. The Wistar Audiogenic Rat (WAR) strain is a model of tonic-clonic seizures induced by acute acoustic stimulation, although it also expresses limbic seizures when repeated acoustic stimulation occurs - a process known as audiogenic kindling (AK). The aim of this study was to evaluate whether or not the olfactory stimulation with TOL would interfere on the behavioral expression of brainstem (acute) and limbic (chronic) seizures in the WAR strain. For this, animals were exposed to TOL or saline (SAL) and subsequently exposed to acoustic stimulation in two conditions that generated: I) acute audiogenic seizures (only one acoustic stimulus, without previous seizure experience before of the odor test) and II) after AK (20 acoustic stimuli [2 daily] before of the protocol test). We observed a decrease in the seizure severity index of animals exposed only to TOL in both conditions, with TOL presented 20Â s before the acoustic stimulation in both protocols. These findings were confirmed by behavioral sequential analysis (neuroethology), which clearly indicated an exacerbation of clusters of specific behaviors such as exploration and grooming (self-cleaning), as well as significant decrease in the expression of brainstem and limbic seizures in response to TOL. Thus, these data demonstrate that TOL, a strong olfactory stimulus, has anticonvulsant properties, detected by the decrease of acute and AK seizures in WARs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy & Behavior - Volume 79, February 2018, Pages 213-224
Journal: Epilepsy & Behavior - Volume 79, February 2018, Pages 213-224
نویسندگان
Polianna Delfino-Pereira, Poliana Bertti-Dutra, Eduardo Henrique de Lima Umeoka, José Antônio Cortes de Oliveira, Victor Rodrigues Santos, Artur Fernandes, Simone Saldanha Marroni, Flávio Del Vecchio, Norberto Garcia-Cairasco,