کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8683935 | 1579863 | 2018 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Seizure remission and improvement of neurological function in sialidosis with perampanel therapy
ترجمه فارسی عنوان
سرگیجه تشنج و بهبود عملکرد نورولوژیکی در سیلیدوز با درمان پردامنل
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
A 15-year-old boy experienced myoclonic seizures for 3Â years. He initially had occasional myoclonus, gradually progressive ataxia, tremors, and psychomotor and speech regression developed. Eventually, he exhibited nearly continuous myoclonus. He received treatment of sodium valproate, levetiracetam, clobazam, and phenobarbital, without efficacy. A ketogenic diet also proved ineffective. Adjunctive therapy with 4Â mg/day of perampanel was started and was gradually titrated to 10Â mg/day. The remission of myoclonic seizures was achieved within one month. The patient's neurological and cognitive functions improved to a certain degree during the following 20Â months. Sialidosis was confirmed by the mutations of NEU1 gene.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy & Behavior Case Reports - Volume 10, 2018, Pages 32-34
Journal: Epilepsy & Behavior Case Reports - Volume 10, 2018, Pages 32-34
نویسندگان
Su-Ching Hu, Kun-Long Hung, Hui-Ju Chen, Wang-Tso Lee,