کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8684579 | 1580131 | 2018 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The effect of myelotomy following low thoracic spinal cord compression injury in rats
ترجمه فارسی عنوان
تاثیر میلوتومی پس از آسیب فشاری کمر درد در موشهای صحرایی نر
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
چکیده انگلیسی
Myelotomy is a surgical procedure allowing removal of extravasated blood and necrotic tissue that is thought to attenuate secondary injury as well as promote recovery in experimental spinal cord injury (SCI) models and humans. Here we examined in rat whether myelotomy at 48â¯h after low-thoracic compressive SCI provided any benefit over a 12â¯week period. Compared to animals receiving SCI alone, myelotomy worsened BBB scores (pâ¯<â¯0.05) and also did not improve plantar stepping, ladder climbing, urinary bladder voiding or sensory function (thermal latency) during the 12-week period. Quantitative analyses of tissue sections at 12â¯weeks showed that myelotomy also did not reduce lesion volume nor alter immunohistochemical markers of axons in spared white matter bridges, microglia, astrocytes or serotinergic fibres. However, myelotomy reduced synaptophysin expression, a marker of synaptic plasticity. We conclude that further studies are required to evaluate myelotomy after SCI. (142 words).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Neurology - Volume 306, August 2018, Pages 10-21
Journal: Experimental Neurology - Volume 306, August 2018, Pages 10-21
نویسندگان
Carolin Meyer, Habib Bendella, Svenja Rink, Robin Gensch, Robert Seitz, Gregor Stein, Marilena Manthou, Theodora Papamitsou, Makoto Nakamura, Bertil Bouillon, Mary Galea, Peter Batchelor, Sarah Dunlop, Doychin Angelov,