کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8684795 1580141 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cellular models as tools for the study of the role of alpha-synuclein in Parkinson's disease
ترجمه فارسی عنوان
مدل های سلولی به عنوان ابزار برای مطالعه نقش آلفا سینوکلین در بیماری پارکینسون
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی
Neurodegenerative diseases are highly debilitating conditions characterised primarily by progressive neuronal loss and impairment of the nervous system. Parkinson's disease (PD) is one of the most common of these disorders, affecting 1-2% of the population above the age of 65. Although the underlying mechanisms of PD have been extensively studied, we still lack a full understanding of the molecular underpinnings of the disease. Thus, the in vitro and in vivo models currently used are able to only partially recapitulate the typical phenotypes of the disease. Here, we review various cell culture models currently used to study the molecular basis of PD, with a focus on alpha-synuclein-associated molecular pathologies. We also discuss how different cell models may constitute powerful tools for high-throughput screening of molecules capable of modulating alpha-synuclein toxicity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Neurology - Volume 298, Part B, December 2017, Pages 162-171
نویسندگان
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