کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8684946 | 1580206 | 2017 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dural AVM (dAVM) in Cowden disease
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
مغز و اعصاب بالینی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Dural AVM (dAVM) in Cowden disease Dural AVM (dAVM) in Cowden disease](/preview/png/8684946.png)
چکیده انگلیسی
Cowden disease is a rare autosomal dominant disorder first described by Rachel Cowden in 1963 as one of the phosphatase and tensin homolog (PTEN) gene hamartoma tumor syndromes. Commonly affecting multiple systems, patients typically have an increased risk of breast and thyroid cancers as well as macrocephaly and benign hamartomatous growths. Due to the benign nature of many of the symptoms, true prevalence is likely higher than reported rates. Malformations associated with PTEN gene lead to dysregulation of cell proliferation yielding increased risk of neoplasm and frequently benign growths. Associated dysregulation of angiogenesis may result in arteriovenous malformations (AVMs). Intracranial AVMs may be asymptomatic. These AVMs present a risk of rupture and subsequent morbidity and mortality. Those with Cowden disease must be monitored for development of intracranial AVMs. Patients should be made aware that treatment for intracranial AVMs may be invasive and include serial embolization.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Interdisciplinary Neurosurgery - Volume 10, December 2017, Pages 155-158
Journal: Interdisciplinary Neurosurgery - Volume 10, December 2017, Pages 155-158
نویسندگان
Anthony C. DO, Parth MS-IV, Rajneesh MD,