کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
868573 909810 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Man-tailored biomimetic sensor of molecularly imprinted materials for the potentiometric measurement of oxytetracycline
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Man-tailored biomimetic sensor of molecularly imprinted materials for the potentiometric measurement of oxytetracycline
چکیده انگلیسی

A novel biomimetic sensor for the potentiometric transduction of oxytetracycline is presented. The artificial host was imprinted in methacrylic acid and/or acrylamide based polymers. Different amounts of molecularly imprinted and non-imprinted polymers were dispersed in different plasticizing solvents and entrapped in a poly(vinyl chloride) matrix. Only molecularly imprinted based sensors allowed a potentiometric transduction, suggesting the existence of host–guest interactions. These sensors exhibited a near-Nernstian response in steady state evaluations; slopes and detection limits ranged 42–63 mV/decade and 2.5–31.3 μg/mL, respectively. Sensors were independent from the pH of test solutions within 2–5. Good selectivity was observed towards glycine, ciprofloxacin, creatinine, acid nalidixic, sulfadiazine, cysteine, hydroxylamine and lactose. In flowing media, the biomimetic sensors presented good reproducibility (RSD of ±0.7%), fast response, good sensitivity (65 mV/decade), wide linear range (5.0 × 10−5 to 1.0 × 10−2 mol/L), low detection limit (19.8 μg/mL), and a stable baseline for a 5 × 10−3 M citrate buffer (pH 2.5) carrier. The sensors were successfully applied to the analysis of drugs and urine. This work confirms the possibility of using molecularly imprinted polymers as ionophores for organic ion recognition in potentiometric transduction.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosensors and Bioelectronics - Volume 26, Issue 2, 15 October 2010, Pages 566–574
نویسندگان
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