NAP prevents acute cerebral oxidative stress and protects against long-term brain injury and cognitive impairment in a model of neonatal hypoxia-ischemia

► NAP prevents acute hypoxia-ischemia-induced oxidative stress in the brain of neonatal rats. ► NAP protects against long-term cognitive impairments in rats that were subjected to the neonatal hypoxia-ischemia. ► NAP prevents the formation of a long-term brain lesion in rats that were exposed to the neonatal hypoxia-ischemia. ► NAP is a potential novel therapeutic target for the treatment of neonatal hypoxia-ischemia.