کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8690636 1581279 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
L'inflammation microscopique dans la sclérose en plaques : inflammation focale et inflammation diffuse
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
L'inflammation microscopique dans la sclérose en plaques : inflammation focale et inflammation diffuse
چکیده انگلیسی
The basic hallmark of multiple sclerosis pathology is the focal demyelinated plaque; it is visible as a focal T2-hypersignal lesion on MRI and under microscopy perivenular mononuclear cells infiltrates are described associated with demyelination with partial axonal loss. In that focal lesion, lymphocytes and especially CD8+ T cells are well represented but B cells can be found, outnumbered by macrophages with myelin debris. MS is a an inflammatory demyelinating and degenerative chronic and evolving disease where a diffuse inflammation in the tissue is also described early but is more and more prominent over time. This diffuse inflammation in white and grey matter is trapped in the parenchyma without any evident disruption of the blood brain barrier. That chronic diffuse and trapped inflammation is characterized by a prominent activated microglia. Indeed, inflammation remains the key feature in relapsing remitting form as well as in secondary or primary progressive form of MS, and inflammation stay related to the demyelination and axonal loss parameters.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pratique Neurologique - FMC - Volume 8, Issue 4, December 2017, Pages 197-203
نویسندگان
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