کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
869151 | 909822 | 2009 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Early determination of cystic fibrosis by electrochemical chloride quantification in sweat Early determination of cystic fibrosis by electrochemical chloride quantification in sweat](/preview/png/869151.png)
A novel and rapid approach to quantify chloride concentration in sweat for early detection of cystic fibrosis (CF) is shown in this work. Disposable screen-printed sensor (SPS) devices capable to induce sweat and measure the chloride concentration are presented. Pilocarpine, which was forced into de skin by means of iontophoresis, has been used to stimulate the sweat glands. Chloride concentration has been directly measured on the skin by potentiometry. The performance of the devices has been tested in synthetic samples, obtaining good agreement with the Nernst equation. Sensors reproducibility has been analyzed in terms of residual standard deviation (RSD), obtaining a value of 8% (n = 6 and α = 0.05). Finally, the application of these sensors in several volunteers has been carried out. The results were compared with the method generally used in hospitals, obtaining deviations minor than 8%.
Journal: Biosensors and Bioelectronics - Volume 24, Issue 6, 15 February 2009, Pages 1788–1791