کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8698127 | 1584665 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Regulation of defensive function on gingival epithelial cells can prevent periodontal disease
ترجمه فارسی عنوان
تنظیم عملکرد دفاعی در سلول های اپیتلیال لثه می تواند از بیماری های پریودنتال جلوگیری کند
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کلمات کلیدی
اپیتلیوم جانسنیکال، سلول اپیتلیال لثه، پیشگیری از بیماری پریودنتال، مانع اپی تلیال، مهاجرت نوتروفیل، اینترلوکین 8،
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
دندانپزشکی، جراحی دهان و پزشکی
چکیده انگلیسی
Periodontal disease is a bacterial biofilm-associated inflammatory disease that has been implicated in many systemic diseases. A new preventive method for periodontal disease needs to be developed in order to promote the health of the elderly in a super-aged society. The gingival epithelium plays an important role as a mechanical barrier against bacterial invasion and a part of the innate immune response to infectious inflammation in periodontal tissue. The disorganization of cell-cell interactions and subsequent inflammation contribute to the initiation of periodontal disease. These make us consider that regulation of host defensive functions, epithelial barrier and neutrophil activity, may become novel preventive methods for periodontal inflammation. Based on this concept, we have found that several agents regulate the barrier function of gingival epithelial cells and suppress the accumulation of neutrophils in the gingival epithelium. We herein introduce the actions of irsogladine maleate, azithromycin, amphotericin B, and Houttuynia cordata (dokudami in Japanese), which is commonly used in traditional medicine, on the epithelial barrier and neutrophil migration in gingival epithelial cells in vivo and in vitro, in order to provide support for the clinical application of these agents to the prevention of periodontal inflammation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Japanese Dental Science Review - Volume 54, Issue 2, May 2018, Pages 66-75
Journal: Japanese Dental Science Review - Volume 54, Issue 2, May 2018, Pages 66-75
نویسندگان
Tsuyoshi Fujita, Tetsuya Yoshimoto, Mikihito Kajiya, Kazuhisa Ouhara, Shinji Matsuda, Tasuku Takemura, Keiichi Akutagawa, Katsuhiro Takeda, Noriyoshi Mizuno, Hidemi Kurihara,