کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8721511 | 1589407 | 2017 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Systemic manifestations of primary Sjögren's syndrome in the NOD.B10Sn-H2b/J mouse model
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کلمات کلیدی
dsDNAParotid secretory proteinFollicular bronchiolitisCA6RRMBALTSMGM3RssDNAEGMPSPautoantibodiesPSSSSSSingle-stranded DNA - DNA تک رشته ایdouble-stranded DNA - DNA رشته ایRNA recognition motif - RNA تشخیص موتیفSp1 - SP1anti-nuclear autoantibodies - آنتی بادی های ضد هسته ایANA - اصلیBronchus-associated lymphoid tissue - بافت لنفاوی مرتبط با برونکوسSjögren's syndrome - سندرم SjögrenPrimary Sjögren's syndrome - سندرم اولیه Sjögrenrheumatoid factor - عامل روماتوئیدSubmandibular gland - غدد غده هیپوفیزLacrimal gland - غدد لوزالمعده
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Animal models that recapitulate human disease are crucial for the study of Sjögren's Syndrome (SS). While several SS mouse models exist, there are few primary SS (pSS) models that mimic systemic disease manifestations seen in humans. Similar to pSS patients, NOD.B10Sn-H2b/J (NOD.B10) mice develop exocrine gland disease and anti-nuclear autoantibodies. However, the disease kinetics and spectrum of extra-glandular disease remain poorly characterized in this model. Our objective was to characterize local and systemic SS manifestations in depth in NOD.B10 female mice at early and late disease time points. To this end, sera, exocrine tissue, lung, and kidney were analyzed. NOD.B10 mice have robust lymphocytic infiltration of salivary and lacrimal tissue. In addition, they exhibit significant renal and pulmonary inflammation. We identified numerous autoantibodies, including those directed against salivary proteins. In conclusion, the NOD.B10 model recapitulates both local and systemic pSS disease and represents an excellent model for translational studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 183, October 2017, Pages 225-232
Journal: Clinical Immunology - Volume 183, October 2017, Pages 225-232
نویسندگان
Jeremy Kiripolsky, Long Shen, Yichen Liang, Alisa Li, Lakshmanan Suresh, Yun Lian, Quan-Zhen Li, Daniel P. Gaile, Jill M. Kramer,