کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8721529 | 1589407 | 2017 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Circulating B cells in type 1 diabetics exhibit fewer maturation-associated phenotypes
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کلمات کلیدی
NODMFIBCRPMTtransmembrane activator and CAML interactorNonobese diabetic mouseNatural killer cells - سلولهای کشنده طبیعیCoefficient of Variation - ضریب تغییرphotomultiplier tube - لوله فوتومولتیپلیرmean fluorescence intensity - میانگین شدت فلورسانسFas receptor - گیرنده FasB cell receptor - گیرنده سلول B
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Although autoantibodies have been used for decades as diagnostic and prognostic markers in type 1 diabetes (T1D), further analysis of developmental abnormalities in B cells could reveal tolerance checkpoint defects that could improve individualized therapy. To evaluate B cell developmental progression in T1D, immunophenotyping was used to classify circulating B cells into transitional, mature naïve, mature activated, and resting memory subsets. Then each subset was analyzed for the expression of additional maturation-associated markers. While the frequencies of B cell subsets did not differ significantly between patients and controls, some T1D subjects exhibited reduced proportions of B cells that expressed transmembrane activator and CAML interactor (TACI) and Fas receptor (FasR). Furthermore, some T1D subjects had B cell subsets with lower frequencies of class switching. These results suggest circulating B cells exhibit variable maturation phenotypes in T1D. These phenotypic variations may correlate with differences in B cell selection in individual T1D patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 183, October 2017, Pages 336-343
Journal: Clinical Immunology - Volume 183, October 2017, Pages 336-343
نویسندگان
Patrick Hanley, Jennifer A. Sutter, Noah G. Goodman, Yangzhu Du, Debora R. Sekiguchi, Wenzhao Meng, Michael R. Rickels, Ali Naji, Eline T. Luning Prak,