کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8736962 1591288 2018 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Toward universal influenza virus vaccines: from natural infection to vaccination strategy
ترجمه فارسی عنوان
به سمت واکسن های ویروسی جهانی: از عفونت های طبیعی تا استراتژی واکسیناسیون
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی
Conceptually, a universal influenza vaccine should elicit broadly protective antibody responses targeting highly conserved epitope(s) shared by various virus strains. Strategically directing antibody immunity to the conserved hemagglutinin stalk has recently emerged as a promising approach that is substantiated by the identification of naturally occurring, stalk-reactive human antibodies capable of conferring broad protection against influenza virus challenge in animal models. Despite all the advancements, future realization of this strategy still faces many challenges, particularly whether it is able to induce enough of cross-reactive antibody response to protect against pandemic viruses. In this respect, recent in-depth dissections of human immune responses to H7N9 virus and vaccination provide much-needed new insights.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Immunology - Volume 53, August 2018, Pages 1-6
نویسندگان
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