کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8737032 1591289 2018 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of calcium permeable channels in dendritic cell migration
ترجمه فارسی عنوان
نقش کانال های نفوذ پذیر کلسیم در مهاجرت سلول های دندریتیک
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی
Calcium ion (Ca2+) is an essential second messenger involved in multiple cellular and subcellular processes. Ca2+ can be released and sensed globally or locally within cells, providing complex signals of variable amplitudes and time-scales. The key function of Ca2+ in the regulation of acto-myosin contractility has provided a simple explanation for its role in the regulation of immune cell migration. However, many questions remain, including the identity of the Ca2+ stores, channels and upstream signals involved in this process. Here, we focus on dendritic cells (DCs), because their immune sentinel function heavily relies on their capacity to migrate within tissues and later on between tissues and lymphoid organs. Deciphering the mechanisms by which cytoplasmic Ca2+ regulate DC migration should shed light on their role in initiating and tuning immune responses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Immunology - Volume 52, June 2018, Pages 74-80
نویسندگان
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