کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8737103 1407765 2018 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Recent advances in inflammasome biology
ترجمه فارسی عنوان
پیشرفت های اخیر در زیست شناسی التهابی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی
The inflammasome is a complex of proteins that through the activity of caspase-1 and the downstream substrates gasdermin D, IL-1β, and IL-18 execute an inflammatory form of cell death termed pyroptosis. Activation of this complex often involves the adaptor protein ASC and upstream sensors including NLRP1, NLRP3, NLRC4, AIM2, and pyrin, which are activated by different stimuli including infectious agents and changes in cell homeostasis. Here we discuss new regulatory mechanisms that have been identified for the canonical inflammasomes, the most recently identified NLRP9b inflammasome, and the new gasdermin family of proteins that mediate pyroptosis and other forms of regulated cell death.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Immunology - Volume 50, February 2018, Pages 32-38
نویسندگان
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