کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8738303 | 1591528 | 2018 | 29 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Novel intranasal pertussis vaccine based on bacterium-like particles as a mucosal adjuvant
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Novel intranasal pertussis vaccine based on bacterium-like particles as a mucosal adjuvant Novel intranasal pertussis vaccine based on bacterium-like particles as a mucosal adjuvant](/preview/png/8738303.png)
چکیده انگلیسی
Pertussis, or whooping cough, has recently reemerged as a major public health threat despite high levels of vaccination. The development of a novel pertussis vaccine, especially an intranasal (i.n.) vaccine is undoubtedly necessary, and mucosal adjuvants have been explored to enhance the immune response. In the present study, bacterium-like particles (BLPs) were adopted as a mucosal adjuvant for an i.n. pertussis vaccine and evaluated on the ability to induce serum and mucosal antibodies as well as potency against i.n. challenge in mice. Groups with or without aluminum adjuvant were also evaluated through both i.n. and intraperitoneal inoculations. Vaccination with BLPs via the i.n. route led to rapid IgG and IgA production and provided strong protection against inflammation induced by infection. The results support an i.n. pertussis vaccine with BLPs adjuvant as a promising candidate to elicit protective immunity against whooping cough.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunology Letters - Volume 198, June 2018, Pages 26-32
Journal: Immunology Letters - Volume 198, June 2018, Pages 26-32
نویسندگان
Wei Shi, Yiming Kou, Hao Jiang, Feng Gao, Wei Kong, Weiheng Su, Fei Xu, Chunlai Jiang,